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Spaglumic acid
CAS No. 3106-85-2
Spaglumic acid( NAAG,N-Acetylaspartylglutamic acid )
Catalog No. M22700 CAS No. 3106-85-2
Spaglumic acid is a neuropeptide found in millimolar concentrations in the brain.Spaglumic Acid is released upon depolarization by a Ca2+-dependent process and is an agonist at mGluR3 receptors and an antagonist at NMDA receptors.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 10MG | 37 | In Stock |
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| 50MG | 109 | In Stock |
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| 100MG | 161 | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameSpaglumic acid
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NoteResearch use only, not for human use.
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Brief DescriptionSpaglumic acid is a neuropeptide found in millimolar concentrations in the brain.Spaglumic Acid is released upon depolarization by a Ca2+-dependent process and is an agonist at mGluR3 receptors and an antagonist at NMDA receptors.
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DescriptionSpaglumic acid is a neuropeptide found in millimolar concentrations in the brain.Spaglumic Acid is released upon depolarization by a Ca2+-dependent process and is an agonist at mGluR3 receptors and an antagonist at NMDA receptors. Spaglumic Acid is catabolized to N-acetylaspartate and glutamate primarily by glutamate carboxypeptidase II, which is expressed on the extracellular surface of astrocytes.
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In VitroSpaglumic Acid (N-Acetylaspartylglutamate; NAAG) is released upon depolarization by a Ca2+-dependent process and is an agonist at mGluR3 receptors and an antagonist at NMDA receptors. Spaglumic Acid is catabolized to N-acetylaspartate and glutamate primarily by glutamate carboxypeptidase II, which is expressed on the extracellular surface of astrocytes. The levels of Spaglumic Acid and the activity of carboxypeptidase II are altered in a regionally specific fashion in several neuropsychiatric disorders.
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In Vivo——
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SynonymsNAAG,N-Acetylaspartylglutamic acid
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PathwayProteasome/Ubiquitin
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TargetEndogenous Metabolite
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RecptorHuman Endogenous Metabolite
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Research Area——
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Indication——
Chemical Information
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CAS Number3106-85-2
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Formula Weight304.26
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Molecular FormulaC11H16N2O8
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Purity>98% (HPLC)
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SolubilityWater:29 mg/mL(95.31 mM)
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SMILESCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(O)=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Coyle JT. The nagging question of the function of N-acetylaspartylglutamate. Neurobiol Dis. 1997;4(3-4):231-8.
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